Pfizer: 3 Shots Effective Against COVID-19 in Children under 5
2022-05-24
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1Drug companies Pfizer and BioNTech said Monday that three low-dose injections of their COVID-19 vaccine have shown to be effective in protecting children under age five.
2The companies made the announcement after carrying out new experiments, or trials, involving the youngest population group.
3They plan to provide information about the trials to the U.S. Food and Drug Administration, FDA, as soon as this week.
4The estimated 18 million children under five are the only Americans who have not yet been approved to receive a COVID-19 vaccine.
5Pfizer and BioNTech have said the amount of vaccine used in their shots for children under five is much less - about one-tenth lower - than the amount used in injections for adults.
6In earlier trials, researchers for the companies said two shots did not seem quite strong enough to effectively protect young children.
7So they decided to give a third shot to more than 1,600 individuals aged six months to four years.
8The new trial was carried out during last winter's spread of the Omicron version of COVID-19.
9In a statement released Monday, Pfizer and BioNTech said the extra shot increased levels of virus-fighting antibodies in the youngest age group.
10The companies said the levels meet FDA requirements for emergency approval of the vaccine.
11Pfizer and BioNTech said early data suggests the three-shot series is more than 80 percent effective in preventing symptomatic COVID-19.
12However, they noted that those results were based on just 10 symptomatic cases identified through April 29.
13For the study to be complete, researchers need at least 21 cases to make a final declaration of effectiveness.
14Pfizer and BioNTech promised to share the additional data when it is available.
15The companies said the vaccine was generally well-received among trial subjects, with only mild side effects reported.
16It remains unclear how many U.S. parents will vaccinate their children in the youngest age group.
17COVID-19 is generally milder in children than adults.
18And only about 29 percent of five to 11-year-olds in the country have received vaccinations.
19The FDA is also planning to examine data provided by competing vaccine maker Moderna for children under the age of six.
20A group of FDA advisors is set to meet next month to consider use of the two vaccines designed for younger people.
21Moderna released trial data in March showing that its vaccine was safe and provided a similar immune system reaction in children as it did in adults.
22Moderna said two of its vaccine shots were 37 percent effective in preventing infections in two to five-year-olds, and 51 percent effective for children aged six months to two years.
23I'm Bryan Lynn.
1Drug companies Pfizer and BioNTech said Monday that three low-dose injections of their COVID-19 vaccine have shown to be effective in protecting children under age five. 2The companies made the announcement after carrying out new experiments, or trials, involving the youngest population group. They plan to provide information about the trials to the U.S. Food and Drug Administration, FDA, as soon as this week. 3The estimated 18 million children under five are the only Americans who have not yet been approved to receive a COVID-19 vaccine. 4Pfizer and BioNTech have said the amount of vaccine used in their shots for children under five is much less - about one-tenth lower - than the amount used in injections for adults. 5In earlier trials, researchers for the companies said two shots did not seem quite strong enough to effectively protect young children. So they decided to give a third shot to more than 1,600 individuals aged six months to four years. The new trial was carried out during last winter's spread of the Omicron version of COVID-19. 6In a statement released Monday, Pfizer and BioNTech said the extra shot increased levels of virus-fighting antibodies in the youngest age group. The companies said the levels meet FDA requirements for emergency approval of the vaccine. 7Pfizer and BioNTech said early data suggests the three-shot series is more than 80 percent effective in preventing symptomatic COVID-19. However, they noted that those results were based on just 10 symptomatic cases identified through April 29. 8For the study to be complete, researchers need at least 21 cases to make a final declaration of effectiveness. Pfizer and BioNTech promised to share the additional data when it is available. 9The companies said the vaccine was generally well-received among trial subjects, with only mild side effects reported. 10It remains unclear how many U.S. parents will vaccinate their children in the youngest age group. COVID-19 is generally milder in children than adults. And only about 29 percent of five to 11-year-olds in the country have received vaccinations. 11The FDA is also planning to examine data provided by competing vaccine maker Moderna for children under the age of six. A group of FDA advisors is set to meet next month to consider use of the two vaccines designed for younger people. 12Moderna released trial data in March showing that its vaccine was safe and provided a similar immune system reaction in children as it did in adults. 13Moderna said two of its vaccine shots were 37 percent effective in preventing infections in two to five-year-olds, and 51 percent effective for children aged six months to two years. 14I'm Bryan Lynn. 15The Associated Press and Reuters reported this story. Bryan Lynn adapted the reports for VOA Learning English. 16We want to hear from you. Write to us in the Comments section, and visit our Facebook page. 17____________________________________________________________________ 18Words in This Story 19dose - n. the amount of a medicine, drug or vitamin that is taken at one time 20symptom - n. a change in the body or mind which indicates that a disease is present 21mild - adj. not severe 22immune system - n. the cells and tissue in the body that fight against infection